Overstimulation of the inhibitory nervous system plays a role in the pathogenesis of neuromuscular and neurological diseases: a novel hypothesis.
Based upon a thorough review of published clinical observations regarding the inhibitory system, Dr. Bert Tuk hypothesized that this system may play a key role in the pathogenesis of a variety of neuromuscular and neurological diseases. Specifically, excitatory overstimulation (leading to irreversible neuronal cell death), which is commonly reported in neuromuscular and neurological diseases, may be a homeostatic response to inhibitory overstimulation. (Direct) involvement of the inhibitory system in disease pathogenesis is highly relevant, given that most approaches currently being developed for treating neuromuscular and neurological diseases focus on reducing excitatory activity rather than reducing (initially reversible) inhibitory activity.
This hypothesis is published in a peer reviewed online journal and can be found through the following link
Relevance for ALS (amyotrophic lateral sclerosis)
Dr. Bert Tuk subsequently hypothesised that syphilis is actually a confounding factor, not a causative factor, in syphilitic ALS (1). Moreover, he proposed that the successful treatment of ALS symptoms in patients with syphilitic ALS using penicillin G and hydrocortisone (3,4) is an indirect consequence of the treatment regimen and is not due to the treatment of syphilis. Specifically, he proposed that the observed effect is due to the various pharmacological activities of penicillin G (e.g., a GABA receptor antagonist (5)) and/or the multifaceted (e.g., anti-inflammatory) pharmacological activity of hydrocortisone. The notion that syphilis may be a confounding factor in syphilitic ALS is highly relevant, as it suggests that treating ALS patients with penicillin G (6) and hydrocortisone (7) - regardless of whether they present with syphilitic ALS or non-syphilitic ALS - may be effective at treating this rapidly progressive, highly devastating disease.
This hypothesis is also published in a peer reviewed online journal and can be found through the following link